We are waiting for the results from her test for the MDR1 gene. The flavored, chewable tablets were consumed . (Basically, I did the boring work to bring you the helpful information.). I was using Seresto collars and am on the hunt for something else. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. enough to have 4 dogs like I do! Dogs and cats . Children should be kept away from the dog for 2 hours until the liquid has had time to dry, and be sure to wash your hands after application. I found some good information on the Cyphenothrin in Parastar Plus in this article. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. Any thoughts on either of these? Dr. Morgan concluded her story with: Be your pets advocate. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Thanks. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. Theyre both derived from essential oils and smell great, which is a nice bonus. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . , Thanks for the reply! Thank you!! Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. From the standpoint of MDR1 dogs, it is safe. (Theres also a hyperlink to her article.) It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. Simparica is administered once a month as a flavored chewable. What an awesome article. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. Thank you for fostering! In summary, use with caution. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Also, Permethrin is one of the active ingredients in K9 Advantix II, an effective spot-on product Ive used on my Aussie mix with no ill effects. Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. Some remain safe, others should be avoided. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines ("-laner" medications) I discussed in the article. For the majority of dogs, Advecta is probably fine! . Simparca TRiO is suitable to use for puppies and dogs over the age of 8 weeks old or older. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. All Rights Reserved. But remember, dogs can also be sensitive to essential oils just like my friend who is allergic to lavender so natural doesnt automatically mean best for your dog either. (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) . Will you be updating this article with regard to Seresto? These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. Thank You so much for your quick response Emily!! The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. Second, Id like to ask a question if you dont mind. Waxman and Brooks both recommend it. However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. Thanks for reply. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. Please tell me if I am wrong. Thank you! We will get her in about 3 weeks. Thank you for bringing this to my attention! If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. ? If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. My Aussie/Pyrenees mix has had no issues with it, for instance. SIMPARICA TRIO killed fleas before they could lay eggs for 35 days. Your sense of humor is enlightening also. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. I follow this advice, since Im a safe-is-better-than-sorry person. collies. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). Thank you for the reminder! Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? The majority of canines will be fine, but there are enough who will react. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. To help with this, the product can be applied in more than one line between the neck and shoulder blades. Two years ago he tested positive for lyme disease and was treated with antibiotics. Thank you for the positive feedback. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. I honestly didnt know they existed until I started researching more to answer your question. Before I got them home, they went into comas. Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. It probably is the safest as it is aimed only at preventing heartworm. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. (There are other places, but none more affordable that Ive found.) Product Description. Enjoy your girl! Simparica Trio treats and protects against harmful parasites. (I have to give them baths with a very mild or medicated shampoo.) Great summary! My plan is to adopt a senior Border to go with my lazy Roughs. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. The accidental ingestion of the product may potentially result in . Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. Best of luck with your girl. Simparica Trio is an all-in-one monthly chewable treatment for dogs. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. On the downside, its efficacy only lasts for about a day. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. Sarolaner is an . The topical medicines seem to work best with her, but dont do much to keep the tics at bay. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Corrosivity My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Give Hollie Collie a good butt scratch or ear rub from me. (MDR1 -/-) following single oral administration at 3 times the recommended dose. FREE delivery Tue, Mar 7. I tried Seresto with my girl and she had a seizure. 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